Date: 7 months ago   Category: Science

The way of fight against incurable cancer is called


Scientists of the University of California of San Francisco have found a new way of treatment of malignant tumors which don't give in to usual therapy. It is reported in the press release on MedicalXpress. About 50 percent of cases of cancer arise because of violations in the alarm ways controlling growth of cages. One of such ways is MAPK/ERK which plays an important role in growth of malignant new growths. He is carried out via the difficult cascade of the interacting proteins. Start of the cascade happens when alarm connection contacts proteinaceous receptors from outer side of a cage. As a result on an internal surface of a cell membrane protein of RAS which transmits a signal to protein of RAF, and further to MEK and MAPK is activated. As a result the wide range of the programs aimed at growth and reproduction of cages is activated. Regulatory proteins NF1 keep activity of MAPK/ERK within healthy range. However the mutations occurring in genes which code components of an alarm way can lead to the intensive growth of cages and development of a tumor. Many attempts of development of the medicines aimed at MAPK/ERK have failed because in malignant fabrics there are roundabout alarm ways, and defective proteins almost don't interact with medicinal substances. It agrees one of hypotheses, mutations do components too sensitive to chemical signals. To check it, scientists used the experimental RMC-4550 connection which inhibits activity of protein SHP2. It is shown that SHP2 causes activation by receptor proteins of the molecule RAS. Results of testing of medicine on the cultures of cancer cells in which there were mutations in genes of NF1 and other important components have shown that tumors stopped the growth. It is more than important news in Film of Day Telegram-channel. Subscribe!

URL:




Today

just now

The Minister of Culture Vladimir Medinsky responded to words of the leader of the Leningrad group Sergey Shnurov that in one country of the world there is no similar to Ministry of Culture of departme...

just now

The former Minister of Economic Development of the Russian Federation Alexey Ulyukaev condemned for a bribe was wished happy birthday by the management of colony and group where he is. The deputy head...

just now

The head coach of the Madrid Real Zinedine Zidane held a personal meeting with the midfielder Marko Asencio and told it that in the next season he will become the key team player. Marca reports about...

just now

The Russian figure skater Alina Zagitova told that she after the free skating in the World Cup stayed in Japan from nine in the evening till five in the morning waiting for doping test. Words of the s...

just now

At the aircraft repair plant in Minsk passed tests of the plane of the Navy of Russia of Tu-134UBL. Video is posted on YouTube. The plane with an inscription onboard Black Sea Fleet and the image of a dolphin after jog on a runway took off on three-hour flight. Tu-134UBL is intended for training of cadets in flights at the Tu-22M3 bombers. The clas...

just now

The Russian SU-27 fighters from structure of forces on duty on air defense twice were lifted per day in air for escort of the American B-52H bombers of the U.S. Air Force over neutral waters of Baltic...

just now

The fan of Moscow Spartak Nikolay Surin on Twitter told that he met on the plane of the football player of Lokomotiv and Russian national team Dmitry Barinov. It forced the athlete to speak for the wo...

16 minutes ago

The singer Natalya Oreyro during emergence on a TV show "Evening Urgant" addressed to the President of Russia Vladimir Putin in whom she asked to issue her the Russian passport. Radio "Govorit Moskva"...