Date: 4 months ago   Category: Science

The way of fight against incurable cancer is called


Scientists of the University of California of San Francisco have found a new way of treatment of malignant tumors which don't give in to usual therapy. It is reported in the press release on MedicalXpress. About 50 percent of cases of cancer arise because of violations in the alarm ways controlling growth of cages. One of such ways is MAPK/ERK which plays an important role in growth of malignant new growths. He is carried out via the difficult cascade of the interacting proteins. Start of the cascade happens when alarm connection contacts proteinaceous receptors from outer side of a cage. As a result on an internal surface of a cell membrane protein of RAS which transmits a signal to protein of RAF, and further to MEK and MAPK is activated. As a result the wide range of the programs aimed at growth and reproduction of cages is activated. Regulatory proteins NF1 keep activity of MAPK/ERK within healthy range. However the mutations occurring in genes which code components of an alarm way can lead to the intensive growth of cages and development of a tumor. Many attempts of development of the medicines aimed at MAPK/ERK have failed because in malignant fabrics there are roundabout alarm ways, and defective proteins almost don't interact with medicinal substances. It agrees one of hypotheses, mutations do components too sensitive to chemical signals. To check it, scientists used the experimental RMC-4550 connection which inhibits activity of protein SHP2. It is shown that SHP2 causes activation by receptor proteins of the molecule RAS. Results of testing of medicine on the cultures of cancer cells in which there were mutations in genes of NF1 and other important components have shown that tumors stopped the growth. It is more than important news in Film of Day Telegram-channel. Subscribe!

URL:




Today

just now

The US Coast Guard refused exercises in the Arctic because of fears to ask for help of Russia in case of breakage of the only American heavy ice breaker. Business Insider reports about it. According t...

just now

The Namer armored personnel carrier (armored personnel carrier) created in Israel can replace the American M2 Bradley and act as a prototype of the American infantry fighting vehicle of the future, The Popular Mechanics writes. Video of firing practice by anti-tank guided missiles from sliding installation of the machine on YouTube was posted by th...

just now

The co-founder of the Oasis group Noel Gallagher offered the mansion located in the London district Maida Vail for sale. The Mansion Global edition reports about it. The musician expects to sell the r...

just now

Most of Ukrainians spend more than 50 percent of income for food. Results of a research of RIA Novosti demonstrate to it. Luxembourg with an indicator of 8.7 percent became the leader of the rating on...

just now

The independent candidate Oleg Kozhemyako won elections the governor of Primorsky Krai after calculation of 100 percent of votes. About it it is told on the website of the Central Electoral Commission...

just now

The president of Ukraine Petro Poroshenko charged to check all government employees for presence of relatives with the Russian citizenship. He said it during the press conference in Kiev which TV chan...

just now

Belarus denied information that the president of Belarus Alexander Lukashenko held a secret meeting on independence of the republic in "pressure conditions" from Russia. The press secretary of the hea...

just now

The Russian companies will oblige to support import substitution and to pass to "primary use" of domestic software by 2022. Kommersant with reference to the directives for state companies approved by...