Date: 6 months ago   Category: Science

The way of fight against incurable cancer is called


Scientists of the University of California of San Francisco have found a new way of treatment of malignant tumors which don't give in to usual therapy. It is reported in the press release on MedicalXpress. About 50 percent of cases of cancer arise because of violations in the alarm ways controlling growth of cages. One of such ways is MAPK/ERK which plays an important role in growth of malignant new growths. He is carried out via the difficult cascade of the interacting proteins. Start of the cascade happens when alarm connection contacts proteinaceous receptors from outer side of a cage. As a result on an internal surface of a cell membrane protein of RAS which transmits a signal to protein of RAF, and further to MEK and MAPK is activated. As a result the wide range of the programs aimed at growth and reproduction of cages is activated. Regulatory proteins NF1 keep activity of MAPK/ERK within healthy range. However the mutations occurring in genes which code components of an alarm way can lead to the intensive growth of cages and development of a tumor. Many attempts of development of the medicines aimed at MAPK/ERK have failed because in malignant fabrics there are roundabout alarm ways, and defective proteins almost don't interact with medicinal substances. It agrees one of hypotheses, mutations do components too sensitive to chemical signals. To check it, scientists used the experimental RMC-4550 connection which inhibits activity of protein SHP2. It is shown that SHP2 causes activation by receptor proteins of the molecule RAS. Results of testing of medicine on the cultures of cancer cells in which there were mutations in genes of NF1 and other important components have shown that tumors stopped the growth. It is more than important news in Film of Day Telegram-channel. Subscribe!

URL:




Today

just now

The State Duma adopted the law on palliative care in the third final reading, Interfax on Thursday, February 21 tells. "People will be free of charge provided with necessary anesthetics and medical pr...

just now

In 2018 in Russia significant increase in children's cruelty was observed, at the same time the number of teenage crimes decreased. RIA Novosti with reference to the head of department of the organiza...

just now

In Novokuznetsk (Kemerovo region) police officers detained the rapper who robbed the admirers for their "importunity". On Thursday, February 21, in regional government of the Ministry of Internal Affa...

just now

Charge of fraudulent plunder 2.5 billion rubles at Vostochny bank is brought to the founder and the managing partner of Baring Vostok investment fund Michael Kalvi. Reported a source in investigating...

just now

The Federal Security Service (FSS) established the scheme according to which the organized criminal community (OCC) under the leadership of the adviser to the CEO of Gazprom mezhregiongaz Raul Arashuk...

just now

The company of the Israeli military industrial complex Israel Aerospace Industries showed destruction of the Russian helicopters in the commercial of the systems of missile defense (MRSAM). The roller...

just now

The President of Russia Vladimir Putin is dissatisfied with efficiency of performance of its units for protection of business against unreasonable prosecution, the press secretary of the head of state...

just now

The group of activists broke display of the movie "Holiday" of the director Alexey Krasovsky in the center of Moscow. The Moscow agency reports about it. The film session was planned to be held in the...