Date: 8 months ago   Category: Science

The way of fight against incurable cancer is called


Scientists of the University of California of San Francisco have found a new way of treatment of malignant tumors which don't give in to usual therapy. It is reported in the press release on MedicalXpress. About 50 percent of cases of cancer arise because of violations in the alarm ways controlling growth of cages. One of such ways is MAPK/ERK which plays an important role in growth of malignant new growths. He is carried out via the difficult cascade of the interacting proteins. Start of the cascade happens when alarm connection contacts proteinaceous receptors from outer side of a cage. As a result on an internal surface of a cell membrane protein of RAS which transmits a signal to protein of RAF, and further to MEK and MAPK is activated. As a result the wide range of the programs aimed at growth and reproduction of cages is activated. Regulatory proteins NF1 keep activity of MAPK/ERK within healthy range. However the mutations occurring in genes which code components of an alarm way can lead to the intensive growth of cages and development of a tumor. Many attempts of development of the medicines aimed at MAPK/ERK have failed because in malignant fabrics there are roundabout alarm ways, and defective proteins almost don't interact with medicinal substances. It agrees one of hypotheses, mutations do components too sensitive to chemical signals. To check it, scientists used the experimental RMC-4550 connection which inhibits activity of protein SHP2. It is shown that SHP2 causes activation by receptor proteins of the molecule RAS. Results of testing of medicine on the cultures of cancer cells in which there were mutations in genes of NF1 and other important components have shown that tumors stopped the growth. It is more than important news in Film of Day Telegram-channel. Subscribe!

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