Date: 10 months ago   Category: Science

The USA has approved intervention in genes of the person


The management on sanitary inspection behind quality of foodstuff and medicines of the USA (FDA) has for the first time approved the medicine intended for treatment of a hereditary transtiretinovy amiloidoz (hATTR). The Science Alert edition reports about it. Medicine патизиран blocks synthesis of the mutated protein of a transtiretin (TTR) which in a normal form transfers hormone of a thyroid gland тиротин and vitamin Retinolum. Defective protein contributes to the development of an amiloidoz when in fabrics there is an accumulation proteinaceous полисахаридного a complex — an amiloid. Amyloid plaques promote dysfunction of fabrics and bodies, including hearts. The mechanism of suppression of activity of a transtiretin is based on a RNA interference when the expression of this or that gene is suppressed by means of small molecules RNA (siPHK). This process begins with cutting of long molecules of the alien two-chained RNA (belonging to viruses) on separate fragments. These parts are included the RISC complex which then connects to the complementary sequences of matrix RNA (MRNK) and activate their cutting. Thereby process of broadcasting and synthesis of protein which has been coded in MRNK is prevented. It is more than important news in Film of Day Telegram-channel. Subscribe!

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