Date: 7 months ago   Category: Science

The new way of fight against incurable cancer is found


Scientists of Hokkaido University (Japan) have revealed the mechanism which promotes growth of cancer tumors, steady against radiation therapy. It is reported in the press release on MedicalXpress. They have found out that in malignant cages there is a metabolic way participating in movement of mitochondrions to an external membrane that increases ability of cancer to get into healthy fabrics. It is known that on a surface of cages there is a protein интегрин which promotes their interaction with an extracellular matriks. Signals which arrive from the integrin contacting from outer side of a membrane certain molecules initiate such processes as movement of organellas in cytoplasm, attachment of a cage to other cages (adhesion) and also differentiation and death. Researchers have shown that accumulation of an integrin leads to formation of an adhesive complex on a cage surface that, in turn, in an alarm way of Arf6-AMP1-PRKD2, promotes a congestion of mitochondrions in the periphery of a cage. Blocking of signals has helped to prevent movement of organellas from the center and to reduce invasiveness of cancer cells. Besides, mitochondrions began to mark out a large number of active forms of oxygen that led to an oxidizing stress and death of malignant cages. According to experts, opening will help to increase efficiency of radiation therapy to which some types of malignant new growths gain stability. It is more than important news in Film of Day Telegram-channel. Subscribe!

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