Date: a week ago   Category: Science

The new way of fight against especially dangerous cancer is open


Scientists of the University of Texas in Houston (USA) have found out that normalization of circadian rhythms allows to suppress growth of especially dangerous cancer tumors of a liver. It is reported in the press release on MedicalXpress. Circadian rhythms call fluctuations of intensity of various biological processes connected with change of day and night, including a metabolism, a dream, wakefulness, reception and digestion of food, and depending on a day regimen. It is known that the correct daily rhythm increases life expectancy of an organism and reduces risk of cancer, and violation of biorhythms, on the contrary, provokes development of various diseases. Researchers have defined an isoform of a nuclear factor of hepatocytes 4 alpha (HNF4α) which suppresses functioning of a gene of BMAL1 participating in formation of a circadian rhythm and active in cells of a liver. This isoform called by P2-HNF4α differs in the properties from P1-HNF4α which depends on circadian rhythms and inhibits the genes provoking development of cancer. P2-HNF4α begins to be synthesized at a specific transcription of a gene of HNF4α operated by the alternative pro-motor. It is shown that about a half of cells of tumor of a gepatotsellyulyarny carcinoma, one of the most killing forms of cancer, make the P2-HNF4α isoform which causes circadian dysfunction. When scientists have increased activity of a gene of BMAL1 operating work of P1-HNF4α, malignant cages have begun to perish. Results show that support of circadian rhythms really helps with prevention and cancer therapy. It is more than important news in Film of Day Telegram-channel. Subscribe!

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