Date: 6 months ago   Category: Science

The main reason of constant hunger and obesity is called


The international group of scientists has found the mechanism which provokes development of obesity and is connected with resistance to a leptin (hormone of control of weight). It is reported in the press release on MedicalXpress. Molecules of a leptin are allocated from cells of white fatty tissue during meal. Through a blood-groove hormone gets into a brain, into a hypothalamus where interacts with proteins on a surface of neurons. It is shown that people with an excess weight at blood have a lot of leptin, but it doesn't influence their satiety. Such state is called resistance to a leptin, and it is considered that it is responsible for development of obesity. Researchers have found out that at mice who receive a large amount of fats with food the enzyme called by matriksny metalproteinase 2 (MMP-2) which interferes with linking of a leptin with receptors of nervous cages in a hypothalamus is formed. MMP-2 causes injury of receptors. In turn, it blocks signals of the neurons participating in formation of feeling of satiety. Scientists have managed to suppress activity of MMP-2 and to show what in this case лептин begins to contact neurons again that reduces tendency to overeating. Researchers hope that results will help to develop proteinase inhibitor which would be effective for a human body. However presence of the similar mechanism at people still should be confirmed. It is more than important news in Film of Day Telegram-channel. Subscribe!

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