Date: 6 months ago   Category: Science

MSU has found means from aging and a disease of kidneys


Scientists of MSU have studied influence of aging on such key cellular processes as an autofagiya, functioning of mitochondrions and an oxidizing stress. Scientists have also offered perspective methods of treatment of an age renal failure. Results are published in the CellCycle magazine. It is reported in the press release, available Lenta.ru. Autofagiya name process at which cages destroy and process the damaged components. By means of this adaptive mechanism the cellular homeostasis is supported. Autofagiya is activated at certain types of a sharp renal failure and also at sepsis and ischemia of a kidney. When aging the efficiency of an autofagiya falls, there is an accumulation of the oxidized proteins and the damaged organellas, including mitochondrions which normal take part in processes of breath and produce energy. Photo: Egor Plotnikov Researchers have considered the renal pathologies accompanying aging of an organism. They have shown that aging is associated with accumulation of the damaged biological structures in a kidney (proteins, lipids, nucleinic acids, organellas). It is known that restriction of food (unloading and dietary therapy) activates processes of an autofagiya and reduces age pathological changes in a kidney. It is experimentally proved that even short-term decrease in consumption of food (for 30-40 percent within several weeks) can increase resistance of a kidney to development of a sharp renal failure. Except system physiological approach, sometimes apply the pharmacological medicines imitating restriction of caloric content to treatment (for example, рапамицин), however its efficiency for treatment of an old kidney isn't proved yet. Other approach to protection of a kidney is the mitochondrial addressed therapy. At a sharp renal failure even in cages of young organisms of a mitochondrion are strongly damaged, and aging in itself leads to violation of mitochondrial functions. First of all the mitochondrial directed antioxidants, such as MITOTEMRO, SS-31 (Bendavia) peptides and the connections of the Skq.Bolshe group of important news developed in MSU in Film of Day Telegram-channel are distinguished from the connections which have proved the efficiency on experimental models. Subscribe!

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