Date: 9 months ago   Category: Science

Key genes of aging are found


Scientists of the University of Exeter (Great Britain) have defined group of genes which play a key role in the course of aging. They regulate splaysing factors — the molecules defining a way of maturing of information RNA. It is reported in the press release on MedicalXpress. Splaysing name process of cutting the nucleotide sequences (introns) of molecule RNA and sewing together of the remained (ekzon) therefore there is a maturing of a molecule. Thus, introns don't bear information on the amino-acid sequence of polypeptide (protein). Sometimes there is an alternative splaysing when ekzona are cut out or there are introns therefore the same gene can code different polypeptides. An important role in it plays splaysosoma — complexes from RNA and proteins. The splaysing factors defining activity of a splaysosoma, in turn are regulated by transcription factors — other proteins which contact DNA and are capable to activate or "switch off" the corresponding genes. Researchers have shown that blocking of alarm ways of ERK and AKT promotes reduction of the growing old cages and rejuvenation of cellular cultures. The similar effect can achieve through inhibition of key components of these ways — genes of FOX01 and ETV6 coding transcription factors. In this case scientists also noted increase in quantity of factors of a splaysing. Scientists hope that results of a research will help to develop methods of fight against aging and associated diseases, such as chronic inflammation or cancer. It is more than important news in Film of Day Telegram-channel. Subscribe!

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